In the serum of CRC patients and healthy individuals to evaluate Subsequently, we compared the ANGPTL2 concentrations Lines, namely Caco-2, LoVo, WiDr, Colo320, Colo205, CW-2 and Study, we first examined the expression of ANGPTL2 in 7 CRC cell Usefulness of ANGPTL2 in CRC has not yet been investigated. This protein is a clinically useful biomarker for gastric cancer Previously demonstrated that ANGPTL2 is upregulated in a gastricĬancer cell line and in gastric cancer patients, demonstrating that May also be a candidate biomarker for other types of cancer. Those reports raised the possibility that ANGPTL2 EndoĪNGPTL2 is a promising biomarker for diagnosing human lung andīreast cancers. Regulatory factor of chronic inflammation ( 6– 10). Additionally, this protein is reported to be a ANGPTL2 is a secreted protein that regulatesĪngiogenic factors produced by tumor cells play an important role Usefulness of angiopoietin-like protein 2 (ANGPTL2) as a candidateīiomarker for CRC. In this study, we investigated the potential Tumor-associated antigens in the management of CRC patients (CA19-9) are among the most commonly used serum-based C-reactive protein (CRP) and carbohydrate antigen 19-9 The measurement of serum-based tumorīiomarkers is a promising screening method for the detection ofĬRC. Thus, early detection of CRC isĬrucial for maximizing the chances of complete cure ( 2). The likelihood of successful completeĮxcision is therefore significantly increased if surgery is Results in metastasis to other organs, such as the liver, and isĪssociated with higher mortality rates ( 1). Million CRC-related deaths worldwide annually. Malignancy worldwide, with 1.2 million new diagnoses and >0.8 These results suggested that the simultaneous measurement of ANGPTL2, along with previously established serum biomarkers, may increase the likelihood of early detection of CRC.Ĭolorectal cancer (CRC) is the third most common A receiver operating characteristic analysis demonstrated that the diagnostic performance of ANGPTL2 was marginally lower compared with that of the established biomarker C‑reactive protein, but higher compared with that of carbohydrate antigen 19‑9. The serum levels of ANGPTL2 in CRC patients (3.45☑.30 ng/ml) were higher compared with those in healthy controls (2.74☐.64 ng/ml) (P<0.05). We first investigated ANGPTL2 expression in 7 CRC cell lines, among which Colo320, NCC‑CoCK‑115P, Caco‑2 and Colo205 exhibited comparatively high ANGPTL2 expression. In this study, we investigated the feasibility of using angiopoietin‑like protein 2 (ANGPTL2) as a candidate biomarker for CRC. The measurement of serum‑based tumor biomarkers has shown great potential for the detection of CRC. Early CRC detection is therefore crucial for maximizing the chances of complete cure. Disease progression leads to its spread to other organs, such as the liver, and is associated with higher mortality rates. Colorectal cancer (CRC) is the third most common malignancy worldwide.
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